Libelle of note

The Diencephalon in its classic, columnar view was divided into four dorsoventrally arranged columns separated by ventricular sulci: the Epithalamus, the Dorsal thalamus, the Ventral thalamus and the Hypothalamus. Extensive embryological studies made it clear that the thalamic 'columns' are derived from transversely oriented zones, the Prosomeres (see TE). Currently, the (Caudal) Diencephalon is subdivided into three segmental units, which from caudal to rostral, contain in their alar domains the Pretectum (prosomere 1 or P1), the Epithalamus and the Thalamus (P2) and the Ventral thalamus or Prethalamus (P3). The diencephalic basal plate contains the rostral part of the Substantia nigra-VTA complex and some other nuclei, collectively forming the Diencephalic or Prerubral tegmentum between the Mesencephalon and the Hypothalamus. The entire Hypothalamus or Rostral diencephalon arises from the alar and basal components of the secondary prosencephalon. The Preoptic area is one of the subpallial developmental domains (Puelles L, Harrison M, Paxinos G, Watson C 2013 A developmental ontology for the mammalian brain based on the prosomeric model. Trends Neurosci 36:570-578).

Some new items have been added from ten Donkelaar HJ, Tzourio-Mazoyer N, Mai JK (2018) Toward a common terminology for the gyri and sulci of the human cerebral cortex. Front Neuroanat 12:93.

For subdivision of Broca’s area, see Amunts K, Schleicher A, Bürgel U, et al. (1999 Broca’s region revisited: Cytoarchitecture and intersubject variability. J Comp Neurol 412:319-341). The Sulcus diagonalis (of Eberstaller) is a variable branch of the Sulcus lateralis, dividing the Pars opercularis into two parts. The Sulcus radiatus (of Eberstaller) may indent the Pars triangularis from above.

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The Angular and supramarginal gyri form with the Parietal operculum the Lobulus parietalis inferior (Inferior parietal lobule or IPL). The Gyrus angularis (Angular gyrus; BA39) can be further subdivided (see Caspers S, Amunts K, Zilles K 2012 Posterior parietal cortex. In: Mai JK, Paxinos G, eds: The Human Nervous System, 3rd ed. Elsevier, Amsterdam, pp 1036-1035). The Operculum parietale (Parietal operculum) contains four cytoarchitectonic, functionally defined areas OP1-4 (see Eickhoff S, Schleicher A, Zilles K, Amunts K 2006a The human parietal operculum. I. Cytoarchitectonic mapping of subdivisions. Cereb Cortex 16:254-267; Eickhoff S, Amunts K, Mohlberg H, Zilles K 2006b Stereotaxic maps and correlation with functional imaginig results. Cereb Cortex 16:268-279). The Gyrus supramarginalis (Supramarginal gyrus; BA40) can be further subdivided (see Caspers et al. 2012).

The Lobulus parietalis superior (Superior parietal lobule or SPL) can be divided into a Preparietal area (BA5 with subdivisions) and a Superior parietal area (BA7 with subdivisions; see Scheperjans F, Eickhoff SB, Mohlberg H, et al. 2008 Probabilistic maps, cytoarchitectonic morphometry, and variability of areas in human superior parietal cortex. Cereb Cortex 18:2141-2157).

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The Gyrus temporalis superior (Superior temporal gyrus; BA22) is not a homogeneous cortical area; it contains various cytoarchitectonically and functionally distinct cortical areas. Its Pars anterior (Anterior part or Belt area) forms the Secondary auditory cortex (BA42 or A2; see Morosan P, Rademacher J, Schleicher A, et al. 2001 Human primary auditory cortex: Cytoarchitecture, subdivisions and mapping into a spatial reference system. Neuroimage 13:684-701; Zilles and Amunts 2012). Its Pars posterior (Posterior part or Wernicke's area) is a loosely defined region which comprises the Posterior part of BA22 but also parts of the Inferior parietal lobule.

The Dorsal part of the Gyrus temporalis superior contains three Sulci temporales transversi (Transverse temporal sulci): the Planum polare (Polar plane) is separated from the Transverse temporal gyri of Heschl by the Sulcus temporalis transversus anterior (Anterior transverse temporal sulcus), the Gyri temporales transversi (Transverse temporal gyri) are subdivided by the Sulcus temporalis transversus intermedius (Intermediate transverse temporal sulcus), and the Planum temporale (Temporal plane) is separated from the Posterior transverse temporal gyrus by the Sulcus temporalis transversus posterior (Posterior transverse temporal sulcus or Heschl's sulcus; see Duvernoy 1992).

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For the Inferomedial aspect of the Temporal lobe, usually the terms Gyrus temporalis inferior (T3), Gyrus fusiformis (T4) and Gyrus parahippocampalis (T5) are used, separated by the Occipitotemporal and the Collateral sulci.

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The following Gyri orbitales can be distinguished: 1) the Gyrus orbitalis medialis, the gyrus between the olfactory sulcus and the medial orbital sulcus; 2) the Gyrus orbitalis anterior, the cortex rostral to the transverse orbital sulcus; 3) the Gyrus orbitalis posterior, the cortex caudal to the transverse orbital sulcus; and 4) the Gyrus orbitalis lateralis, the gyrus lateral to the lateral orbital sulcus. The caudal parts of the medial and posterior orbital gyri merge to form the Lobulus orbitalis posteromedialis as described by Türe U, Yasargil DCH, Al-Mefti O, Yasargil MC (1999 Topographic anatomy of the insular region. J Neurosurg 90:720-733) and Naidich TP, Kang E, Fatterpekar GM, et al. (2004 The insula: Anatomic study and MR imaging display at 1.5T. AJNR Am J Neuroradiol 25:222-232). Mai and Majtanik (2017 Human Brain in Standard MNI Space. Academic/Elsevier, San Diego) also described a Regio orbitalis posterolateralis.

The Gyrus cingularis (Cingulate gyrus) can at least be divided into an Anterior, a Posterior and a Retrosplenial part. Vogt BA, Palomero-Gallagher N (2012 Cingulate cortex. In: Mai JK, Paxinos G, eds: The Human Nervous System, 3rd ed. Elsevier, Amsterdam, pp 943-987) added a Midcingulate cortex.

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The Uncus is treated in various ways: 1) as the rostral part of the Parahippocampal gyrus; 2) as a structure on its own. TNA suggests the latter. Insausti R and Amaral DG (2012 Hippocampal formation. In: Mai JK, Paxinos G, eds: The Human Nervous System, 3rd ed. Elsevier, Amsterdam, pp 896-942) advocated to restrict the term Uncus to the Gyrus uncinatus, the Band or limbus of Giacomini and the Gyrus intralimbicus (or Uncal apex). The Sulcus semianularis (Semi-anular sulcus) separates the Ambient and Semilunar sulci (see Duvernoy HM 1992, 1998 The Human Hippocampus, 2nd ed. Springer, Berlin-Heidelberg-New York). The Gyrus uncinatus is the most rostral part of Uncal bulge, according to Insausti and Amaral (2012) and part of field CA1. The Limbus fasciae dentatae (Band of dentate gyrus) is the Middle part of the Uncus, first described by Giacomini CH (1884 Fascia dentata du grand hippocampe dans le cerveau de l'homme. Arch Ital Biol 5:1-16, 205-209, 396-417) and part of the Dentate gyrus. The Gyrus intralimbicus (Intralimbic gyrus or Uncal apex) is the most caudal part of the Uncal bulge and part of field CA3.

Under this Heading the structures presented in TA as Substantia basalis, Substantia innominata and Area septalis are grouped. Reichert's 'Substantia innominata' was for a long time a 'terra incognita' of the Basal forebrain. The extensive studies by Heimer and colleagues (Heimer L, Harlan RE, Alheid GF, et al. 1997 Substantia innominata: A notion which impedes clinico-anatomical correlations in neuropsychiatric disorders. Neuroscience 76:957-1006; Heimer et al. 1999; Sakamoto et al. 1999) make the term SI more or less superfluous.

Usually, the Sulcus centralis does not reach the Sulcus lateralis and is separated from it by a short gyrus, the Gyrus subcentralis, which is formed by the 'fusion' of the Precentral and Postcentral gyri in their ventralmost parts. The Subcentral gyrus is delimited in front and behind by the Anterior and Posterior subcentral sulci (Dejerine 1895; Duvernoy 1992; Petrides and Pandya 2012). Also known as: Central or Rolandic operculum, and Inferior frontoparietal 'pli de passage'.

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Field CA4 appears to correspond most closely to the polymorph zone of the Dentate gyrus, and, therefore, is not a field of the Hippocampus at all. Amaral and Insausti (Amaral DG, Insausti R 1990 Hippocampal formation. In: Paxinos G, ed: The Human Nervous System. Academic Press, San Diego, CA, pp 711-755) suggested the term 'CA3h' for the pyramidal cells within the hilus ('h'), continuous with CA3.

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In the French literature, for the Inner ring of the Limbic lobe the term Gyrus intralimbicus is used. In the German literature, however, this term is used for the Uncal apex.

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